/** Split objects into normal and disease components */
private void splitObjects() {
normalIds = new HashSet<Long>();
diseaseIds = new HashSet<Long>();
RenderablePathway diagram = (RenderablePathway) getRenderable();
if (pathway == null || diagram.getReactomeDiagramId() == null) return;
try {
GKInstance pdInst = adaptor.fetchInstance(diagram.getReactomeDiagramId());
// Get the disease pathway instance
List<GKInstance> pathways =
pdInst.getAttributeValuesList(ReactomeJavaConstants.representedPathway);
GKInstance diseasePathway = null;
GKInstance normalPathway = null;
GKInstance disease = (GKInstance) pathway.getAttributeValue(ReactomeJavaConstants.disease);
if (disease == null && contains(pathway, pathways)) {
normalPathway = pathway;
} else {
diseasePathway = pathway;
// There should be a normal pathway contained by a disease pathway
List<?> subPathways = diseasePathway.getAttributeValuesList(ReactomeJavaConstants.hasEvent);
for (Object obj : subPathways) {
GKInstance subPathway = (GKInstance) obj;
disease = (GKInstance) subPathway.getAttributeValue(ReactomeJavaConstants.disease);
if (disease == null && contains(subPathway, pathways)) {
normalPathway = subPathway;
break;
}
}
}
if (normalPathway != null) {
// Get all disease related objects
Set<GKInstance> normalEvents = InstanceUtilities.grepPathwayEventComponents(normalPathway);
for (GKInstance inst : normalEvents) normalIds.add(inst.getDBID());
Set<GKInstance> normalEntities = InstanceUtilities.grepPathwayParticipants(normalPathway);
for (GKInstance inst : normalEntities) normalIds.add(inst.getDBID());
if (diseasePathway != null) {
Set<GKInstance> allEvents = InstanceUtilities.grepPathwayEventComponents(diseasePathway);
allEvents.removeAll(normalEvents);
for (GKInstance inst : allEvents) {
diseaseIds.add(inst.getDBID());
// Want to make sure disease pathways are connected to objects
if (inst.getSchemClass().isa(ReactomeJavaConstants.ReactionlikeEvent)) {
Set<GKInstance> rxtEntities = InstanceUtilities.getReactionParticipants(inst);
for (GKInstance rxtEntity : rxtEntities) {
diseaseIds.add(rxtEntity.getDBID());
}
}
}
// Set<GKInstance> allEntities =
// InstanceUtilities.grepPathwayParticipants(diseasePathway);
// allEntities.removeAll(normalEntities);
// for (GKInstance inst : allEntities)
// diseaseIds.add(inst.getDBID());
}
}
splitComponents();
} catch (Exception e) {
e.printStackTrace();
}
}
