/**
* Gets to the linked PhysicalEntity.
*
* @param match current pattern match
* @param ind mapped indices
* @return linked PhysicalEntity
*/
@Override
public Collection<BioPAXElement> generate(Match match, int... ind) {
PhysicalEntity pe = (PhysicalEntity) match.get(ind[0]);
Set<BioPAXElement> set = getLinkedElements(pe);
return set;
}
/**
* Checks if the generated elements from the first mapped element has either the desired value, or
* has some value in common with the elements generated from second mapped element.
*
* @param match current pattern match
* @param ind mapped indices
* @return true if a value match is found
*/
@Override
public boolean satisfies(Match match, int... ind) {
assertIndLength(ind);
// Collect values of the element group
Set values = new HashSet();
for (BioPAXElement gen : con1.generate(match, ind)) {
values.addAll(pa1.getValueFromBean(gen));
}
// If emptiness is desired, check that
if (value == EMPTY) return values.isEmpty();
// If cannot be empty, check it
if (oper == Operation.NOT_EMPTY_AND_NOT_INTERSECT && values.isEmpty()) return false;
// If the second element is desired value, check that
else if (value == USE_SECOND_ARG) {
BioPAXElement q = match.get(ind[1]);
return oper == Operation.INTERSECT ? values.contains(q) : !values.contains(q);
}
// If element group is compared to preset value, but the value is actually a collection,
// then iterate the collection, see if any of them matches
else if (value instanceof Collection) {
Collection query = (Collection) value;
values.retainAll(query);
if (oper == Operation.INTERSECT) return !values.isEmpty();
else return values.isEmpty();
}
// If two set of elements should share a field value, check that
else if (pa2 != null) {
// Collect values of the second group
Set others = new HashSet();
for (BioPAXElement gen : con2.generate(match, ind)) {
others.addAll(pa2.getValueFromBean(gen));
}
switch (oper) {
case INTERSECT:
others.retainAll(values);
return !others.isEmpty();
case NOT_INTERSECT:
others.retainAll(values);
return others.isEmpty();
case NOT_EMPTY_AND_NOT_INTERSECT:
if (others.isEmpty()) return false;
others.retainAll(values);
return others.isEmpty();
default:
throw new RuntimeException("Unhandled operation: " + oper);
}
}
// Check if the element field values contain the parameter value
else if (oper == Operation.INTERSECT) return values.contains(value);
else return !values.contains(value);
}
/**
* Checks if the controlled Interaction contains a controller as a participant. This constraint
* filters out such cases.
*
* @param match current pattern match
* @param ind mapped indices
* @return true if participants of teh controlled Interactions not also a controller of the
* Control.
*/
@Override
public boolean satisfies(Match match, int... ind) {
Control ctrl = (Control) match.get(ind[0]);
for (Process process : ctrl.getControlled()) {
if (process instanceof Interaction) {
Interaction inter = (Interaction) process;
Set<Entity> participant = inter.getParticipant();
for (Controller controller : ctrl.getController()) {
if (participant.contains(controller)) return false;
}
}
}
return true;
}
/**
* Checks the gained and and lost features to predict the activity change is the desired change.
* If exact matching (terms with locations) is not conclusive, then terms without locations are
* checked. If still not conclusive, then approximate matching is used.
*
* @param match current pattern match
* @param ind mapped indices
* @return true if the modification gain or loss is mapped to the desired change
*/
@Override
public boolean satisfies(Match match, int... ind) {
BioPAXElement ele1 = match.get(ind[0]);
BioPAXElement ele2 = match.get(ind[1]);
EntityReference er = ((SimplePhysicalEntity) ele1).getEntityReference();
Set set1 = pa.getValueFromBean(ele1);
Set set2 = pa.getValueFromBean(ele2);
Set gain = new HashSet(set2);
gain.removeAll(set1);
Set loss = new HashSet(set1);
loss.removeAll(set2);
int activatingCnt = 0;
int inhibitingCnt = 0;
for (Object o : gain) {
if (activityFeat.get(er).contains(o)) activatingCnt++;
if (inactivityFeat.get(er).contains(o)) inhibitingCnt++;
}
for (Object o : loss) {
if (inactivityFeat.get(er).contains(o)) activatingCnt++;
if (activityFeat.get(er).contains(o)) inhibitingCnt++;
}
// Match without considering the locations
Set<String> gainTypes = null;
Set<String> lossTypes = null;
if (activatingCnt + inhibitingCnt == 0) {
gainTypes = extractModifNames(gain);
lossTypes = extractModifNames(loss);
for (String s : gainTypes) {
if (activityStr.get(er).contains(s)) activatingCnt++;
if (inactivityStr.get(er).contains(s)) inhibitingCnt++;
}
for (String s : lossTypes) {
if (inactivityStr.get(er).contains(s)) activatingCnt++;
if (activityStr.get(er).contains(s)) inhibitingCnt++;
}
}
// Try to match modifications with approximate name matching
if (activatingCnt + inhibitingCnt == 0) {
for (String genName : general) {
boolean foundInActivating = setContainsGeneralTerm(activityStr.get(er), genName);
boolean foundInInhibiting = setContainsGeneralTerm(inactivityStr.get(er), genName);
if (foundInActivating == foundInInhibiting) continue;
boolean foundInGain = setContainsGeneralTerm(gainTypes, genName);
boolean foundInLose = setContainsGeneralTerm(lossTypes, genName);
if (foundInGain == foundInLose) continue;
if (foundInActivating && foundInGain) activatingCnt++;
else if (foundInInhibiting && foundInLose) activatingCnt++;
else if (foundInActivating && foundInLose) inhibitingCnt++;
else /*if (foundInInhibiting && foundInGain)*/ inhibitingCnt++;
}
}
if (activatingCnt > 0 && inhibitingCnt > 0) return false;
return activating ? activatingCnt > 0 : inhibitingCnt > 0;
}