/** Split objects into normal and disease components */
  private void splitObjects() {
    normalIds = new HashSet<Long>();
    diseaseIds = new HashSet<Long>();
    RenderablePathway diagram = (RenderablePathway) getRenderable();
    if (pathway == null || diagram.getReactomeDiagramId() == null) return;
    try {
      GKInstance pdInst = adaptor.fetchInstance(diagram.getReactomeDiagramId());
      // Get the disease pathway instance
      List<GKInstance> pathways =
          pdInst.getAttributeValuesList(ReactomeJavaConstants.representedPathway);

      GKInstance diseasePathway = null;
      GKInstance normalPathway = null;
      GKInstance disease = (GKInstance) pathway.getAttributeValue(ReactomeJavaConstants.disease);
      if (disease == null && contains(pathway, pathways)) {
        normalPathway = pathway;
      } else {
        diseasePathway = pathway;
        // There should be a normal pathway contained by a disease pathway
        List<?> subPathways = diseasePathway.getAttributeValuesList(ReactomeJavaConstants.hasEvent);
        for (Object obj : subPathways) {
          GKInstance subPathway = (GKInstance) obj;
          disease = (GKInstance) subPathway.getAttributeValue(ReactomeJavaConstants.disease);
          if (disease == null && contains(subPathway, pathways)) {
            normalPathway = subPathway;
            break;
          }
        }
      }
      if (normalPathway != null) {
        // Get all disease related objects
        Set<GKInstance> normalEvents = InstanceUtilities.grepPathwayEventComponents(normalPathway);
        for (GKInstance inst : normalEvents) normalIds.add(inst.getDBID());
        Set<GKInstance> normalEntities = InstanceUtilities.grepPathwayParticipants(normalPathway);
        for (GKInstance inst : normalEntities) normalIds.add(inst.getDBID());
        if (diseasePathway != null) {
          Set<GKInstance> allEvents = InstanceUtilities.grepPathwayEventComponents(diseasePathway);
          allEvents.removeAll(normalEvents);
          for (GKInstance inst : allEvents) {
            diseaseIds.add(inst.getDBID());
            // Want to make sure disease pathways are connected to objects
            if (inst.getSchemClass().isa(ReactomeJavaConstants.ReactionlikeEvent)) {
              Set<GKInstance> rxtEntities = InstanceUtilities.getReactionParticipants(inst);
              for (GKInstance rxtEntity : rxtEntities) {
                diseaseIds.add(rxtEntity.getDBID());
              }
            }
          }
          //                    Set<GKInstance> allEntities =
          // InstanceUtilities.grepPathwayParticipants(diseasePathway);
          //                    allEntities.removeAll(normalEntities);
          //                    for (GKInstance inst : allEntities)
          //                        diseaseIds.add(inst.getDBID());
        }
      }
      splitComponents();
    } catch (Exception e) {
      e.printStackTrace();
    }
  }
 /**
  * Overlay a single disease reaction onto a normal reaction.
  *
  * @param normalReaction
  * @param diseaseReaction
  * @param overlaidObjects
  */
 private void overlayDiseaseReaction(HyperEdge normalReaction, GKInstance diseaseReaction)
     throws Exception {
   // Make a copy of the HyperEdge for future process that is related to Vertex and JSON generation
   HyperEdge reactionCopy = normalReaction.shallowCopy();
   reactionCopy.setReactomeId(diseaseReaction.getDBID());
   reactionCopy.setDisplayName(diseaseReaction.getDisplayName());
   reactionCopy.setLineColor(DefaultRenderConstants.DEFAULT_DISEASE_BACKGROUND);
   displayedObject.addComponent(reactionCopy);
   overlaidObjects.add(reactionCopy);
   // Want to handle inputs, outputs and catalysts since regulators can
   // be ignored
   List<Node> nodes = new ArrayList<Node>();
   nodes.addAll(normalReaction.getInputNodes());
   nodes.addAll(normalReaction.getOutputNodes());
   nodes.addAll(normalReaction.getHelperNodes());
   // List objects not listed in the disease reaction as crossed objects
   Set<GKInstance> participants = InstanceUtilities.getReactionParticipants(diseaseReaction);
   Set<Long> diseaseIds = new HashSet<Long>();
   for (GKInstance participant : participants) {
     diseaseIds.add(participant.getDBID());
     if (participant.getSchemClass().isValidAttribute(ReactomeJavaConstants.hasMember)) {
       List<GKInstance> list = participant.getAttributeValuesList(ReactomeJavaConstants.hasMember);
       if (list != null && list.size() > 0) {
         for (GKInstance inst : list) diseaseIds.add(inst.getDBID());
       }
     }
     if (participant.getSchemClass().isValidAttribute(ReactomeJavaConstants.hasCandidate)) {
       List<GKInstance> list =
           participant.getAttributeValuesList(ReactomeJavaConstants.hasCandidate);
       if (list != null && list.size() > 0) {
         for (GKInstance inst : list) diseaseIds.add(inst.getDBID());
       }
     }
   }
   Set<GKInstance> lofInstances = new HashSet<GKInstance>();
   Map<Node, GKInstance> normalToDiseaseEntity =
       mapMutatedToNormalNodes(diseaseReaction, normalReaction, nodes, lofInstances);
   for (Node node : nodes) {
     if (!diseaseIds.contains(node.getReactomeId())) {
       // Check if it should be mapped to a normal entity
       GKInstance diseaseEntity = normalToDiseaseEntity.get(node);
       if (diseaseEntity == null) crossedObjects.add(node); // Just crossed out
       else {
         Node diseaseNode =
             replaceNormalNode(node, diseaseEntity, contains(diseaseEntity, lofInstances));
         if (diseaseNode == null) continue; // Just in case
         // Re-link to diseaseNode
         ConnectInfo connectInfo = reactionCopy.getConnectInfo();
         List<?> widgets = connectInfo.getConnectWidgets();
         for (Object obj : widgets) {
           ConnectWidget widget = (ConnectWidget) obj;
           if (widget.getConnectedNode() == node) widget.replaceConnectedNode(diseaseNode);
         }
       }
     } else overlaidObjects.add(node);
   }
 }
 private void clearDeleteRecord() {
   if (deleteList != null) {
     java.util.List list = deleteList.getSelection();
     if (list.size() > 0) {
       try {
         java.util.List dbIDs = new ArrayList(list.size());
         for (Iterator it = list.iterator(); it.hasNext(); ) {
           GKInstance instance = (GKInstance) it.next();
           dbIDs.add(instance.getDBID());
         }
         fileAdaptor.clearDeleteRecord(dbIDs);
       } catch (IOException e) {
         System.err.println("SynchronizationDialog.clearDeleteRecord(): " + e);
         e.printStackTrace();
       }
       deleteList.deleteInstances(list);
       // Check if deleteList needs to be removed
       if (deleteList.getDisplayedInstances().size() == 0) {
         centerPane.remove(deleteList);
         centerPane.validate();
         centerPane.repaint();
       }
     }
   }
 }
 public void randomlyMapDiseaseNodesToNormalNodes(
     Map<Node, GKInstance> normalToDiseaseEntity,
     Collection<GKInstance> mapped,
     List<GKInstance> diseaseInputs,
     List<Node> normalNodes) {
   if (diseaseInputs != null && diseaseInputs.size() > 0) {
     normalNodes.removeAll(normalToDiseaseEntity.keySet());
     if (normalNodes.size() > 0) {
       for (GKInstance input : diseaseInputs) {
         // if (mapped.contains(input))
         if (contains(input, mapped)) continue; // it has been mapped already
         // Check if it has been used based on DB_ID
         Node matched = null;
         for (Node node : normalNodes) {
           if (node.getReactomeId().equals(input.getDBID())) {
             matched = node;
             break;
           }
         }
         if (matched == null)
           // Just pick up the first node
           matched = normalNodes.get(0);
         normalToDiseaseEntity.put(matched, input);
         normalNodes.remove(matched);
         if (normalNodes.size() == 0) break;
       }
     }
   }
 }
 /**
  * Some of disease reactions may not be drawn in the pathway diagram (e.g. LoF or GoF reactions).
  * These reactions should be overlaid onto their normalReaction counterparts, which are encoded by
  * their normalReaction attributes.
  *
  * @param diseaseIds
  */
 private void overlayDiseaseReactions(Set<Long> diseaseIds) {
   // Get the list of all drawing objects for checking
   Map<Long, Renderable> idToObject = new HashMap<Long, Renderable>();
   List<Renderable> components = displayedObject.getComponents();
   if (components == null || components.size() == 0) return;
   for (Renderable r : components) {
     if (r.getReactomeId() == null) continue;
     idToObject.put(r.getReactomeId(), r);
   }
   try {
     normalToDiseaseNode = new HashMap<Node, Node>();
     for (Long diseaseId : diseaseIds) {
       if (idToObject.containsKey(diseaseId)) continue;
       // Have to copy the normal reactions to draw
       GKInstance inst = adaptor.fetchInstance(diseaseId);
       if (inst.getSchemClass().isa(ReactomeJavaConstants.ReactionlikeEvent)) {
         List<GKInstance> normalReactions =
             inst.getAttributeValuesList(ReactomeJavaConstants.normalReaction);
         if (normalReactions != null && normalReactions.size() > 0) {
           for (GKInstance normalRxt : normalReactions) {
             Renderable r = idToObject.get(normalRxt.getDBID());
             if (r instanceof HyperEdge) overlayDiseaseReaction((HyperEdge) r, inst);
           }
         }
       }
     }
     return;
   } catch (Exception e) {
     e.printStackTrace();
   }
 }
 private Node replaceNormalNode(
     Node normalNode, GKInstance diseaseEntity, Boolean needDashedBorder) {
   Node diseaseNode = normalToDiseaseNode.get(normalNode);
   if (diseaseNode != null) return diseaseNode;
   try {
     // If a node exists already, it should use
     for (Renderable r : diseaseComps) {
       if (diseaseEntity.getDBID().equals(r.getReactomeId()) && r instanceof Node) {
         // This is rather arbitrary: if two nodes are very close,
         // use the existing one.
         int dx = Math.abs(r.getPosition().x - normalNode.getPosition().x);
         int dy = Math.abs(r.getPosition().y - normalNode.getPosition().y);
         if (dx < 10 && dy < 10) {
           // We don't need to create a new Node if it exists already
           normalToDiseaseNode.put(normalNode, (Node) r);
           overlaidObjects.add(r); // Add it to overlaid object to cover edges
           return (Node) r;
         }
       }
     }
     diseaseNode = normalNode.getClass().newInstance();
     RenderUtility.copyRenderInfo(normalNode, diseaseNode);
     // The following should NOT be called since NodeAttachment is
     // related to disease entity only.
     // TODO: Need to support this. Currently it is not supported!!! See example
     // in PI3/AKT cancer pathway.
     // diseaseNode.setNodeAttachmentsLocally(node.getNodeAttachments());
     diseaseNode.setDisplayName(diseaseEntity.getDisplayName());
     diseaseNode.setReactomeId(diseaseEntity.getDBID());
     diseaseNode.invalidateBounds();
     diseaseNode.setRenderer(normalNode.getRenderer());
     diseaseNode.setLineColor(DefaultRenderConstants.DEFAULT_DISEASE_BACKGROUND);
     diseaseNode.setNeedDashedBorder(needDashedBorder);
     RenderUtility.hideCompartmentInNodeName(diseaseNode);
     overlaidObjects.add(diseaseNode);
     displayedObject.addComponent(diseaseNode);
     normalToDiseaseNode.put(normalNode, diseaseNode);
     return diseaseNode;
   } catch (Exception e) {
     e.printStackTrace();
   }
   return null;
 }
Exemplo n.º 7
0
 private void convertReactomeToGPML(GKInstance pathway, String outputFileName) throws Exception {
   Long dbID = pathway.getDBID();
   System.out.println("converting pathway #" + dbID + " " + pathway.getDisplayName() + "...");
   Document doc = r2gConverter.convertPathway(pathway);
   XMLOutputter outputter = new XMLOutputter(Format.getPrettyFormat());
   outputter.output(doc, new FileOutputStream(outputFileName));
   /*
   // Test loading using JDOM and validation
   SAXBuilder builder = new SAXBuilder(true);
   builder.setFeature("http://apache.org/xml/features/validation/schema", true);
   builder.setProperty("http://apache.org/xml/properties/schema/external-schemaLocation",
                       "http://genmapp.org/GPML/2008a http://svn.bigcat.unimaas.nl/pathvisio/trunk/GPML2008a.xsd");
   doc = builder.build(new File(outputFileName));
   */
 }
Exemplo n.º 8
0
 /**
  * This method is used to dump all human pathway diagrams into a specified directory.
  *
  * @param dir
  * @throws Exception
  */
 public void dumpHumanPathwayDiagrams(File dir) throws Exception {
   Collection<?> diagrams = adaptor.fetchInstancesByClass(ReactomeJavaConstants.PathwayDiagram);
   SchemaClass cls = adaptor.fetchSchema().getClassByName(ReactomeJavaConstants.PathwayDiagram);
   SchemaAttribute att = cls.getAttribute(ReactomeJavaConstants.representedPathway);
   adaptor.loadInstanceAttributeValues(diagrams, att);
   // Group all human pathways
   for (Iterator<?> it = diagrams.iterator(); it.hasNext(); ) {
     GKInstance diagram = (GKInstance) it.next();
     GKInstance pathway =
         (GKInstance) diagram.getAttributeValue(ReactomeJavaConstants.representedPathway);
     GKInstance species = (GKInstance) pathway.getAttributeValue(ReactomeJavaConstants.species);
     if (species == null) continue;
     if (species.getDBID().equals(48887L)) {
       String fileName = getFileName(pathway);
       File file = new File(dir, fileName);
       convertReactomeToGPML(pathway, file.getAbsolutePath());
     }
   }
 }
Exemplo n.º 9
0
 public boolean shouldEscape(GKInstance inst) {
   if (!needEscapePermissioin) return false;
   if (needEscape && escapedDbIds.contains(inst.getDBID())) {
     if (cutoffDate != null) {
       try {
         // Check if the latest IEs is later than the cutoff date
         GKInstance latestIE = InstanceUtilities.getLatestIEFromInstance(inst);
         // Just in case
         if (latestIE == null) return true;
         String ieDateValue = (String) latestIE.getAttributeValue(ReactomeJavaConstants.dateTime);
         // Have to make sure default date instance is used!
         DateFormat df = new SimpleDateFormat("yyyy-MM-dd HH:mm:ss.S");
         Date ieDate = df.parse(ieDateValue);
         return !ieDate.after(cutoffDate);
       } catch (Exception e) {
         // Don't want to show a GUI here. Just generate error message silently.
         System.err.println("QAEscapeHelper.shouldEscape(): " + e);
         e.printStackTrace();
         return false;
       }
     } else return true;
   }
   return false;
 }
  private void showComparison() {
    // Find the instance that can be used for comparision. This instance
    // should be chosen from changedList or localHasUnexpInstance
    GKInstance instance = null;
    if (changedList != null) { // Check changedList first
      List selection = changedList.getSelection();
      if (selection.size() > 0) instance = (GKInstance) selection.get(0);
    }
    if (instance == null && localHasMoreIEList != null) {
      List selection = localHasMoreIEList.getSelection();
      if (selection.size() > 0) instance = (GKInstance) selection.get(0);
    }
    if (instance == null) return;
    final InstanceComparisonPane comparisonPane = new InstanceComparisonPane();
    // Fine tune comparison pane for making comparisons with
    // database
    comparisonPane.setSaveDialogHideUnusedButtons(true);
    comparisonPane.setSaveDialogSaveAsNewBtnFirst(false);
    comparisonPane.setSaveDialogSaveAsNewBtnTitle(
        "Create new local instance and put merge into that");
    comparisonPane.setSaveDialogReplaceFirstBtnTitle(
        "Overwrite existing instance with merge (recommended)");
    comparisonPane.setCloseAfterSaving(true);
    try {
      String clsName = instance.getSchemClass().getName();
      Long instanceId = instance.getDBID();
      final GKInstance localCopy = fileAdaptor.fetchInstance(clsName, instanceId);
      dbAdaptor.setUseCache(false);
      // final GKInstance dbCopy = dbAdaptor.fetchInstance(clsName, instanceId);
      // The class type might be changed locally or remotely. So not clsName should be used
      // to fetch database instance. Otherwise, null exception will be thrown. The same thing
      // is done also in creating synchronization result.
      final GKInstance dbCopy = dbAdaptor.fetchInstance(instanceId);
      dbAdaptor.setUseCache(true);
      comparisonPane.setInstances(localCopy, dbCopy);
      String title =
          "Comparing Instances \""
              + instance.getDisplayName()
              + "\" in the local and DB repositories";
      JDialog parentDialog = (JDialog) SwingUtilities.getAncestorOfClass(JDialog.class, centerPane);
      final JDialog dialog = new JDialog(parentDialog, title);
      // Try to update the list automatically
      dialog.addWindowListener(
          new WindowAdapter() {
            public void windowClosed(WindowEvent e) {
              handleMergeResult(localCopy, dbCopy, comparisonPane);
              // To prevent double calling. It is called again when parentDialog is closed.
              dialog.removeWindowListener(this);
            }
          });
      dialog.getContentPane().add(comparisonPane, BorderLayout.CENTER);
      dialog.setModal(true);
      dialog.setSize(800, 600);
      GKApplicationUtilities.center(dialog);
      dialog.setVisible(true);

      // Update synchronization dialog panels depending on user
      // choice.
      if (comparisonPane.getSaveMergeOption() == InstanceComparisonPane.SAVE_AS_NEW) {
        GKInstance merged = comparisonPane.getMerged();

        if (newList == null) {
          List list = new ArrayList();
          list.add(merged);
          newList = initInstanceListPane(list, "Instances created locally: " + list.size());
        } else newList.addInstance(merged);
      } else if (comparisonPane.getSaveMergeOption() == InstanceComparisonPane.OVERWRITE_FIRST) {
        dbAdaptor.setUseCache(false);
        GKInstance remoteCopy = dbAdaptor.fetchInstance(instance.getDBID());
        dbAdaptor.setUseCache(true);
        if (remoteCopy != null) {
          InstanceComparer comparer = new InstanceComparer();
          int reply = comparer.compare(instance, remoteCopy);
          if (reply == InstanceComparer.LOCAL_HAS_MORE_IE) {
            if (localHasMoreIEList == null) {
              List list = new ArrayList();
              list.add(instance);
              localHasMoreIEList =
                  initInstanceListPane(
                      list, "Local instances having unexpected InstanceEdits: " + list.size());
            } else localHasMoreIEList.addInstance(instance);
          } else if (reply == InstanceComparer.IS_IDENTICAL) {
            // Merge has made local and database copies
            // identical - don't need to check in anymore
            changedList.deleteInstance(instance);
          } else if (reply != InstanceComparer.NEW_CHANGE_IN_LOCAL) {
            // Merge has produced a conflict
            typeMap.put(mapCompareResultToString(reply), instance);
          } else
            // The user should now be allowed to commit this
            // instance, because it will now have changed.
            commitToDBAction.setEnabled(true);

          JOptionPane.showMessageDialog(
              parentDialog,
              "Merge successful, you will need to check the merged instance into the database.\n\n",
              "Merge OK",
              JOptionPane.INFORMATION_MESSAGE);
        }
      }

    } catch (Exception e1) {
      System.err.println("Synchronization.createDisplayMapPane(): " + e1);
      e1.printStackTrace();
      JOptionPane.showMessageDialog(
          this,
          "Error in comparing: " + instance.toString(),
          "Error in Comparing",
          JOptionPane.ERROR_MESSAGE);
    }
  }
 private void updateFromDB() {
   InstanceListPane touchedList = null;
   // Find out which instances have been selected in all relevant lists
   // Update the attribute values for changed list.
   try {
     if (changedList != null) {
       java.util.List list = new ArrayList(changedList.getSelection()); // To support it.remove()
       // Use a new ArrayList.
       if (list != null && list.size() > 0) {
         for (Iterator it = list.iterator(); it.hasNext(); ) {
           GKInstance instance = (GKInstance) it.next();
           // Fetch GKInstance based on its DB_ID since SchemaClass might be changed.
           GKInstance localCopy = fileAdaptor.fetchInstance(instance.getDBID());
           dbAdaptor.setUseCache(false);
           GKInstance dbCopy = dbAdaptor.fetchInstance(instance.getDBID());
           dbAdaptor.setUseCache(true);
           if (SynchronizationManager.getManager().updateFromDB(localCopy, dbCopy, this)) {
             AttributeEditManager.getManager().attributeEdit(localCopy);
             fileAdaptor.removeDirtyFlag(localCopy);
           } else it.remove(); // Remove from the list
         }
         // Remove all selected instances
         changedList.deleteInstances(list);
         touchedList = changedList;
       }
     }
     if (localHasMoreIEList != null && localHasMoreIEList.getSelection().size() > 0) {
       List list = new ArrayList(localHasMoreIEList.getSelection());
       for (Iterator it = list.iterator(); it.hasNext(); ) {
         GKInstance localCopy = (GKInstance) it.next();
         dbAdaptor.setUseCache(false);
         GKInstance dbCopy = dbAdaptor.fetchInstance(localCopy.getDBID());
         dbAdaptor.setUseCache(true);
         if (SynchronizationManager.getManager().updateFromDB(localCopy, dbCopy, this)) {
           AttributeEditManager.getManager().attributeEdit(localCopy);
           fileAdaptor.removeDirtyFlag(localCopy);
         } else it.remove(); // Remove from the list, if it it cancelled by the user.
       }
       localHasMoreIEList.deleteInstances(list);
       touchedList = localHasMoreIEList;
     }
     // Delete the local copy for deleteInDBList.
     if (deleteInDBList != null) {
       java.util.List list = deleteInDBList.getSelection();
       if (list != null && list.size() > 0) {
         for (Iterator it = list.iterator(); it.hasNext(); ) {
           GKInstance instance = (GKInstance) it.next();
           fileAdaptor.deleteInstance(instance);
         }
       }
       deleteInDBList.deleteInstances(list);
       touchedList = deleteInDBList;
     }
     // Get another copy for the local repository
     if (deleteList != null) {
       java.util.List<?> list = deleteList.getSelection();
       if (list != null && list.size() > 0) {
         Map<SchemaClass, Set<GKInstance>> checkOutMap =
             new HashMap<SchemaClass, Set<GKInstance>>(); // All checked out Instances
         for (Iterator<?> it = list.iterator(); it.hasNext(); ) {
           GKInstance instance = (GKInstance) it.next();
           Map<SchemaClass, List<GKInstance>> schemaMap =
               InstanceUtilities.listDownloadableInstances(instance);
           // Have to merge schemaMap to checkOutMap
           for (SchemaClass key : schemaMap.keySet()) {
             List<GKInstance> list1 = schemaMap.get(key);
             if (list1 != null && list1.size() > 0) {
               Set<GKInstance> list2 = checkOutMap.get(key);
               if (list2 == null) {
                 list2 = new HashSet<GKInstance>();
                 checkOutMap.put(key, list2);
               }
               // Remove first to avoid any duplication
               list2.addAll(list1);
             }
           }
         }
         fileAdaptor.store(checkOutMap);
         InstanceUtilities.clearShellFlags(checkOutMap);
         // There are maybe more than selected instances after checking out
         List<GKInstance> checkedOut = new ArrayList<GKInstance>();
         for (Set<GKInstance> set : checkOutMap.values()) {
           checkedOut.addAll(set);
         }
         deleteList.deleteInstances(checkedOut);
         // deleteList.deleteInstances(list);
         // Need to clear out these deletion records
         List<Long> dbIds = new ArrayList<Long>();
         for (GKInstance inst : checkedOut) dbIds.add(inst.getDBID());
         fileAdaptor.clearDeleteRecord(dbIds);
         touchedList = deleteList;
       }
     }
   } catch (Exception e) {
     System.err.println("SynchronizationDialog.updateFromDB(): " + e);
     e.printStackTrace();
   }
   updateInstanceList(touchedList);
 }
Exemplo n.º 12
0
 /**
  * In case where MySQLAdaptor cache is turned off, GKInstances having the same DB_IDs from the
  * database are different during different queries. Using this helper method to check if a
  * GKInstance is contained in a Collection<GKInstance> created in different time point.
  *
  * @param inst
  * @param c
  * @return
  */
 private boolean contains(GKInstance inst, Collection<GKInstance> c) {
   for (GKInstance inst1 : c) {
     if (inst1.getDBID().equals(inst.getDBID())) return true;
   }
   return false;
 }