private EnrichmentEngineResponseDto computeEnrichment(EnrichmentEngineRequestDto request)
     throws ApplicationException, NoRelatedGenesInfoException {
   if (request == null) {
     return null;
   }
   if (request.getNodes().size() == 0) {
     throw new NoRelatedGenesInfoException();
   }
   return mania.computeEnrichment(request);
 }