/** Split objects into normal and disease components */
private void splitObjects() {
normalIds = new HashSet<Long>();
diseaseIds = new HashSet<Long>();
RenderablePathway diagram = (RenderablePathway) getRenderable();
if (pathway == null || diagram.getReactomeDiagramId() == null) return;
try {
GKInstance pdInst = adaptor.fetchInstance(diagram.getReactomeDiagramId());
// Get the disease pathway instance
List<GKInstance> pathways =
pdInst.getAttributeValuesList(ReactomeJavaConstants.representedPathway);
GKInstance diseasePathway = null;
GKInstance normalPathway = null;
GKInstance disease = (GKInstance) pathway.getAttributeValue(ReactomeJavaConstants.disease);
if (disease == null && contains(pathway, pathways)) {
normalPathway = pathway;
} else {
diseasePathway = pathway;
// There should be a normal pathway contained by a disease pathway
List<?> subPathways = diseasePathway.getAttributeValuesList(ReactomeJavaConstants.hasEvent);
for (Object obj : subPathways) {
GKInstance subPathway = (GKInstance) obj;
disease = (GKInstance) subPathway.getAttributeValue(ReactomeJavaConstants.disease);
if (disease == null && contains(subPathway, pathways)) {
normalPathway = subPathway;
break;
}
}
}
if (normalPathway != null) {
// Get all disease related objects
Set<GKInstance> normalEvents = InstanceUtilities.grepPathwayEventComponents(normalPathway);
for (GKInstance inst : normalEvents) normalIds.add(inst.getDBID());
Set<GKInstance> normalEntities = InstanceUtilities.grepPathwayParticipants(normalPathway);
for (GKInstance inst : normalEntities) normalIds.add(inst.getDBID());
if (diseasePathway != null) {
Set<GKInstance> allEvents = InstanceUtilities.grepPathwayEventComponents(diseasePathway);
allEvents.removeAll(normalEvents);
for (GKInstance inst : allEvents) {
diseaseIds.add(inst.getDBID());
// Want to make sure disease pathways are connected to objects
if (inst.getSchemClass().isa(ReactomeJavaConstants.ReactionlikeEvent)) {
Set<GKInstance> rxtEntities = InstanceUtilities.getReactionParticipants(inst);
for (GKInstance rxtEntity : rxtEntities) {
diseaseIds.add(rxtEntity.getDBID());
}
}
}
// Set<GKInstance> allEntities =
// InstanceUtilities.grepPathwayParticipants(diseasePathway);
// allEntities.removeAll(normalEntities);
// for (GKInstance inst : allEntities)
// diseaseIds.add(inst.getDBID());
}
}
splitComponents();
} catch (Exception e) {
e.printStackTrace();
}
}
protected List getSynchronizingClassList(XMLFileAdaptor fileAdaptor) {
GKSchemaClass topCls = selectedCls;
if (topCls == null)
topCls = (GKSchemaClass) ((GKSchema) fileAdaptor.getSchema()).getRootClass();
List clsList = new ArrayList();
InstanceUtilities.getDescendentClasses(clsList, topCls);
return clsList;
}
/**
* Overlay a single disease reaction onto a normal reaction.
*
* @param normalReaction
* @param diseaseReaction
* @param overlaidObjects
*/
private void overlayDiseaseReaction(HyperEdge normalReaction, GKInstance diseaseReaction)
throws Exception {
// Make a copy of the HyperEdge for future process that is related to Vertex and JSON generation
HyperEdge reactionCopy = normalReaction.shallowCopy();
reactionCopy.setReactomeId(diseaseReaction.getDBID());
reactionCopy.setDisplayName(diseaseReaction.getDisplayName());
reactionCopy.setLineColor(DefaultRenderConstants.DEFAULT_DISEASE_BACKGROUND);
displayedObject.addComponent(reactionCopy);
overlaidObjects.add(reactionCopy);
// Want to handle inputs, outputs and catalysts since regulators can
// be ignored
List<Node> nodes = new ArrayList<Node>();
nodes.addAll(normalReaction.getInputNodes());
nodes.addAll(normalReaction.getOutputNodes());
nodes.addAll(normalReaction.getHelperNodes());
// List objects not listed in the disease reaction as crossed objects
Set<GKInstance> participants = InstanceUtilities.getReactionParticipants(diseaseReaction);
Set<Long> diseaseIds = new HashSet<Long>();
for (GKInstance participant : participants) {
diseaseIds.add(participant.getDBID());
if (participant.getSchemClass().isValidAttribute(ReactomeJavaConstants.hasMember)) {
List<GKInstance> list = participant.getAttributeValuesList(ReactomeJavaConstants.hasMember);
if (list != null && list.size() > 0) {
for (GKInstance inst : list) diseaseIds.add(inst.getDBID());
}
}
if (participant.getSchemClass().isValidAttribute(ReactomeJavaConstants.hasCandidate)) {
List<GKInstance> list =
participant.getAttributeValuesList(ReactomeJavaConstants.hasCandidate);
if (list != null && list.size() > 0) {
for (GKInstance inst : list) diseaseIds.add(inst.getDBID());
}
}
}
Set<GKInstance> lofInstances = new HashSet<GKInstance>();
Map<Node, GKInstance> normalToDiseaseEntity =
mapMutatedToNormalNodes(diseaseReaction, normalReaction, nodes, lofInstances);
for (Node node : nodes) {
if (!diseaseIds.contains(node.getReactomeId())) {
// Check if it should be mapped to a normal entity
GKInstance diseaseEntity = normalToDiseaseEntity.get(node);
if (diseaseEntity == null) crossedObjects.add(node); // Just crossed out
else {
Node diseaseNode =
replaceNormalNode(node, diseaseEntity, contains(diseaseEntity, lofInstances));
if (diseaseNode == null) continue; // Just in case
// Re-link to diseaseNode
ConnectInfo connectInfo = reactionCopy.getConnectInfo();
List<?> widgets = connectInfo.getConnectWidgets();
for (Object obj : widgets) {
ConnectWidget widget = (ConnectWidget) obj;
if (widget.getConnectedNode() == node) widget.replaceConnectedNode(diseaseNode);
}
}
} else overlaidObjects.add(node);
}
}
private void buildTree(Collection instances, DefaultMutableTreeNode parentNode) throws Exception {
if (instances == null || instances.size() == 0) return;
List list = new ArrayList(instances);
InstanceUtilities.sortInstances(list);
for (Iterator it = list.iterator(); it.hasNext(); ) {
GKInstance inst = (GKInstance) it.next();
DefaultMutableTreeNode treeNode = new DefaultMutableTreeNode(inst);
parentNode.add(treeNode);
}
}
private InstanceListPane initInstanceListPane(List instances, String title) {
InstanceListPane instanceList = new InstanceListPane();
instanceList.getInstanceList().addListSelectionListener(selectionListener);
instanceList.setIsViewable(false);
if (mouseAdaptor == null) {
// To view instances
mouseAdaptor =
new MouseAdapter() {
public void mousePressed(MouseEvent e) {
if (e.isPopupTrigger()) doPopup(e);
}
public void mouseReleased(MouseEvent e) {
if (e.isPopupTrigger()) doPopup(e);
}
// Use mouseClicked method. See InstanceListPane.init().
public void mouseClicked(MouseEvent e) {
if (e.getButton() == MouseEvent.BUTTON1 && e.getClickCount() == 2) {
JList list = (JList) e.getSource();
if (list.getSelectedValues().length != 1) return;
InstanceListPane instanceList = figureOutInstanceListPane(list);
if (instanceList == changedList || instanceList == localHasMoreIEList) {
showComparison();
} else {
GKInstance instance = (GKInstance) list.getSelectedValue();
JDialog parentDialog =
(JDialog) SwingUtilities.getAncestorOfClass(JDialog.class, centerPane);
FrameManager.getManager().showInstance(instance, parentDialog);
}
}
}
};
}
instanceList.getInstanceList().addMouseListener(mouseAdaptor);
InstanceUtilities.sortInstances(instances);
instanceList.setDisplayedInstances(instances);
// instanceList.setTitle(title);
instanceList.setListCellRenderer(cellRenderer);
instanceList.hideTitle();
SectionTitlePane titlePane = new SectionTitlePane(title);
titlePane.setSectionPane(instanceList);
centerPane.add(titlePane);
centerPane.add(instanceList);
listToTitle.put(instanceList, titlePane);
return instanceList;
}
private Set<GKInstance> getReferenceEntity(GKInstance pe) throws Exception {
Set<GKInstance> rtn = new HashSet<GKInstance>();
if (pe.getSchemClass().isValidAttribute(ReactomeJavaConstants.referenceEntity)) {
GKInstance ref = (GKInstance) pe.getAttributeValue(ReactomeJavaConstants.referenceEntity);
if (ref != null) rtn.add(ref);
return rtn;
}
Set<GKInstance> contained =
InstanceUtilities.getContainedInstances(
pe,
ReactomeJavaConstants.hasMember,
ReactomeJavaConstants.hasCandidate,
ReactomeJavaConstants.hasComponent);
// Check member or complex subunits
for (GKInstance tmp : contained) {
if (tmp.getSchemClass().isValidAttribute(ReactomeJavaConstants.referenceEntity)) {
GKInstance ref = (GKInstance) tmp.getAttributeValue(ReactomeJavaConstants.referenceEntity);
if (ref != null) rtn.add(ref);
}
}
return rtn;
}
public boolean shouldEscape(GKInstance inst) {
if (!needEscapePermissioin) return false;
if (needEscape && escapedDbIds.contains(inst.getDBID())) {
if (cutoffDate != null) {
try {
// Check if the latest IEs is later than the cutoff date
GKInstance latestIE = InstanceUtilities.getLatestIEFromInstance(inst);
// Just in case
if (latestIE == null) return true;
String ieDateValue = (String) latestIE.getAttributeValue(ReactomeJavaConstants.dateTime);
// Have to make sure default date instance is used!
DateFormat df = new SimpleDateFormat("yyyy-MM-dd HH:mm:ss.S");
Date ieDate = df.parse(ieDateValue);
return !ieDate.after(cutoffDate);
} catch (Exception e) {
// Don't want to show a GUI here. Just generate error message silently.
System.err.println("QAEscapeHelper.shouldEscape(): " + e);
e.printStackTrace();
return false;
}
} else return true;
}
return false;
}
private void updateFromDB() {
InstanceListPane touchedList = null;
// Find out which instances have been selected in all relevant lists
// Update the attribute values for changed list.
try {
if (changedList != null) {
java.util.List list = new ArrayList(changedList.getSelection()); // To support it.remove()
// Use a new ArrayList.
if (list != null && list.size() > 0) {
for (Iterator it = list.iterator(); it.hasNext(); ) {
GKInstance instance = (GKInstance) it.next();
// Fetch GKInstance based on its DB_ID since SchemaClass might be changed.
GKInstance localCopy = fileAdaptor.fetchInstance(instance.getDBID());
dbAdaptor.setUseCache(false);
GKInstance dbCopy = dbAdaptor.fetchInstance(instance.getDBID());
dbAdaptor.setUseCache(true);
if (SynchronizationManager.getManager().updateFromDB(localCopy, dbCopy, this)) {
AttributeEditManager.getManager().attributeEdit(localCopy);
fileAdaptor.removeDirtyFlag(localCopy);
} else it.remove(); // Remove from the list
}
// Remove all selected instances
changedList.deleteInstances(list);
touchedList = changedList;
}
}
if (localHasMoreIEList != null && localHasMoreIEList.getSelection().size() > 0) {
List list = new ArrayList(localHasMoreIEList.getSelection());
for (Iterator it = list.iterator(); it.hasNext(); ) {
GKInstance localCopy = (GKInstance) it.next();
dbAdaptor.setUseCache(false);
GKInstance dbCopy = dbAdaptor.fetchInstance(localCopy.getDBID());
dbAdaptor.setUseCache(true);
if (SynchronizationManager.getManager().updateFromDB(localCopy, dbCopy, this)) {
AttributeEditManager.getManager().attributeEdit(localCopy);
fileAdaptor.removeDirtyFlag(localCopy);
} else it.remove(); // Remove from the list, if it it cancelled by the user.
}
localHasMoreIEList.deleteInstances(list);
touchedList = localHasMoreIEList;
}
// Delete the local copy for deleteInDBList.
if (deleteInDBList != null) {
java.util.List list = deleteInDBList.getSelection();
if (list != null && list.size() > 0) {
for (Iterator it = list.iterator(); it.hasNext(); ) {
GKInstance instance = (GKInstance) it.next();
fileAdaptor.deleteInstance(instance);
}
}
deleteInDBList.deleteInstances(list);
touchedList = deleteInDBList;
}
// Get another copy for the local repository
if (deleteList != null) {
java.util.List<?> list = deleteList.getSelection();
if (list != null && list.size() > 0) {
Map<SchemaClass, Set<GKInstance>> checkOutMap =
new HashMap<SchemaClass, Set<GKInstance>>(); // All checked out Instances
for (Iterator<?> it = list.iterator(); it.hasNext(); ) {
GKInstance instance = (GKInstance) it.next();
Map<SchemaClass, List<GKInstance>> schemaMap =
InstanceUtilities.listDownloadableInstances(instance);
// Have to merge schemaMap to checkOutMap
for (SchemaClass key : schemaMap.keySet()) {
List<GKInstance> list1 = schemaMap.get(key);
if (list1 != null && list1.size() > 0) {
Set<GKInstance> list2 = checkOutMap.get(key);
if (list2 == null) {
list2 = new HashSet<GKInstance>();
checkOutMap.put(key, list2);
}
// Remove first to avoid any duplication
list2.addAll(list1);
}
}
}
fileAdaptor.store(checkOutMap);
InstanceUtilities.clearShellFlags(checkOutMap);
// There are maybe more than selected instances after checking out
List<GKInstance> checkedOut = new ArrayList<GKInstance>();
for (Set<GKInstance> set : checkOutMap.values()) {
checkedOut.addAll(set);
}
deleteList.deleteInstances(checkedOut);
// deleteList.deleteInstances(list);
// Need to clear out these deletion records
List<Long> dbIds = new ArrayList<Long>();
for (GKInstance inst : checkedOut) dbIds.add(inst.getDBID());
fileAdaptor.clearDeleteRecord(dbIds);
touchedList = deleteList;
}
}
} catch (Exception e) {
System.err.println("SynchronizationDialog.updateFromDB(): " + e);
e.printStackTrace();
}
updateInstanceList(touchedList);
}
