/**
* Gets a list of the affected genes.
*
* @param selected is the list of selected genes.
* @return the list of affected genes.
*/
public ArrayList<ArrayList<Gene>> getAffected(ArrayList<Gene> selected) {
ArrayList<ArrayList<Gene>> results = new ArrayList<ArrayList<Gene>>();
for (ArrayList<Gene> x : causes) {
boolean conditions = true;
// check if the list of conditions are met.
int j = 0;
while (conditions == true && j < x.size()) {
boolean gene_found = false;
int i = 0;
Gene gene_x = x.get(j);
// check input list against condision
while (gene_found == false && i < selected.size()) {
if (gene_x.equals(selected.get(i))) {
gene_found = true;
}
i++;
}
if (gene_found == false) {
conditions = false;
}
j++;
}
if (conditions == true) {
results.add(x);
}
}
return results;
}
/**
* Checks if any of the conditions for the disease are met.
*
* @param selected is the list of selected genes.
* @return true if conditions met.
*/
public boolean isAffected(ArrayList<Gene> selected) {
for (ArrayList<Gene> x : causes) {
boolean conditions = true;
// check if the list of conditions are met.
int j = 0;
while (conditions == true && j < x.size()) { // goes through sub list
Gene gene_x = x.get(j); // gets current gene
boolean gene_found = false;
int i = 0;
// check input list against condition
while (gene_found == false && i < selected.size()) {
if (gene_x.equals(selected.get(i))) {
gene_found = true;
}
i++;
}
if (gene_found == false) {
conditions = false;
}
j++;
}
if (conditions == true) {
return true;
}
}
return false;
}
/**
* Provides implementation-independent means for creating new Gene instances. The new instance
* that is created and returned should be setup with any implementation-dependent configuration
* that this Gene instance is setup with (aside from the actual value, of course). For example, if
* this Gene were setup with bounds on its value, then the Gene instance returned from this method
* should also be setup with those same bounds. This is important, as the JGAP core will invoke
* this method on each Gene in the sample Chromosome in order to create each new Gene in the same
* respective gene position for a new Chromosome.
*
* @return a new Gene instance of the same type and with the same setup as this concrete Gene
* @author Neil Rostan
* @author Klaus Meffert
* @since 2.6 (since 1.0 in IntegerGene)
*/
public Gene newGene() {
Gene result = newGeneInternal();
result.setConstraintChecker(getConstraintChecker());
result.setEnergy(getEnergy());
/** @todo clone app.data */
result.setApplicationData(getApplicationData());
return result;
}
/**
* Verifies the state of the chromosome. Especially takes care of the given constraint checker.
*
* @param a_constraintChecker the constraint checker to verify
* @throws InvalidConfigurationException
* @author Klaus Meffert
* @since 2.5
*/
protected void verify(IGeneConstraintChecker a_constraintChecker)
throws InvalidConfigurationException {
if (a_constraintChecker != null && getGenes() != null) {
int len = getGenes().length;
for (int i = 0; i < len; i++) {
Gene gene = getGene(i);
if (!a_constraintChecker.verify(gene, null, this, i)) {
throw new InvalidConfigurationException(
"The gene type "
+ gene.getClass().getName()
+ " is not allowed to be used in the chromosome due to the"
+ " constraint checker used.");
}
}
}
}
/**
* Retrieve a hash code for this Chromosome. Does not considers the order of the Genes for all
* cases (especially when gene is empty).
*
* @return the hash code of this Chromosome
* @author Neil Rotstan
* @author Klaus Meffert
* @since 1.0
*/
public int hashCode() {
// Do what java.util.AbstractList does.
// ------------------------------------
int geneHashcode;
int hashCode = 1;
if (getGenes() != null) {
int size = size();
for (int i = 0; i < size; i++) {
Gene gene = getGene(i);
if (gene == null) {
geneHashcode = -55;
} else {
geneHashcode = gene.hashCode();
}
hashCode = 31 * hashCode + geneHashcode;
}
}
return hashCode;
}
/**
* Compares this Gene with the given object and returns true if the other object is a Gene of the
* same type and has the same value (allele) as this Gene. Otherwise it returns false.
*
* @param a_other the object to compare to this Gene for equality
* @return true if this Gene is equal to the given object, false otherwise
* @author Klaus Meffert
* @since 1.1
*/
public boolean equals(final Object a_other) {
try {
int result = compareTo(a_other);
if (result == 0) {
if (isCompareApplicationData()) {
Gene otherGene = (Gene) a_other;
int resultAppData =
compareApplicationData(getApplicationData(), otherGene.getApplicationData());
return resultAppData == 0;
} else {
return true;
}
} else {
return false;
}
} catch (ClassCastException e) {
// If the other object isn't an Gene of current type
// (like IntegerGene for IntegerGene's), then we're not equal.
// -----------------------------------------------------------
return false;
}
}
protected void initFromGene(Gene a_sampleGene) {
// Do sanity checking to make sure the parameters we were
// given are valid.
// ------------------------------------------------------
if (a_sampleGene == null) {
throw new IllegalArgumentException("Sample Gene cannot be null.");
}
// Populate the array of genes it with new Gene instances
// created from the sample gene.
// ------------------------------------------------------
int size = size();
for (int i = 0; i < size; i++) {
setGene(i, a_sampleGene.newGene());
}
}
private void addGene(
Map<String, Gene> map, String gene, String chr, long start, long end, long len) {
if (map.containsKey(gene)) {
Gene geneObj = map.get(gene);
// move start
if (geneObj.getStart() > start) {
geneObj.setStart(start);
}
// move end
if (geneObj.getEnd() < end) {
geneObj.setEnd(end);
}
// update length
geneObj.setLen(geneObj.getLen() + len);
} else {
Gene geneObj = new Gene(gene, chr, start, end, len);
map.put(gene, geneObj);
}
}
/**
* Unmarshall a Chromosome instance from a given XML Element representation.
*
* @param a_activeConfiguration current Configuration object
* @param a_xmlElement the XML Element representation of the Chromosome
* @return a new Chromosome instance setup with the data from the XML Element representation
* @throws ImproperXMLException if the given Element is improperly structured or missing data
* @throws UnsupportedRepresentationException if the actively configured Gene implementation does
* not support the string representation of the alleles used in the given XML document
* @throws GeneCreationException if there is a problem creating or populating a Gene instance
* @author Neil Rotstan
* @since 1.0
*/
public static Gene[] getGenesFromElement(
Configuration a_activeConfiguration, Element a_xmlElement)
throws ImproperXMLException, UnsupportedRepresentationException, GeneCreationException {
// Do some sanity checking. Make sure the XML Element isn't null and
// that it in fact represents a set of genes.
// -----------------------------------------------------------------
if (a_xmlElement == null || !(a_xmlElement.getTagName().equals(GENES_TAG))) {
throw new ImproperXMLException(
"Unable to build Chromosome instance from XML Element: "
+ "given Element is not a 'genes' element.");
}
List genes = Collections.synchronizedList(new ArrayList());
// Extract the nested gene elements.
// ---------------------------------
NodeList geneElements = a_xmlElement.getElementsByTagName(GENE_TAG);
if (geneElements == null) {
throw new ImproperXMLException(
"Unable to build Gene instances from XML Element: "
+ "'"
+ GENE_TAG
+ "'"
+ " sub-elements not found.");
}
// For each gene, get the class attribute so we know what class
// to instantiate to represent the gene instance, and then find
// the child text node, which is where the string representation
// of the allele is located, and extract the representation.
// -------------------------------------------------------------
int numberOfGeneNodes = geneElements.getLength();
for (int i = 0; i < numberOfGeneNodes; i++) {
Element thisGeneElement = (Element) geneElements.item(i);
thisGeneElement.normalize();
// Fetch the class attribute and create an instance of that
// class to represent the current gene.
// --------------------------------------------------------
String geneClassName = thisGeneElement.getAttribute(CLASS_ATTRIBUTE);
Gene thisGeneObject;
Class geneClass = null;
try {
geneClass = Class.forName(geneClassName);
try {
Constructor constr = geneClass.getConstructor(new Class[] {Configuration.class});
thisGeneObject = (Gene) constr.newInstance(new Object[] {a_activeConfiguration});
} catch (NoSuchMethodException nsme) {
// Try it by calling method newGeneInternal.
// -----------------------------------------
Constructor constr = geneClass.getConstructor(new Class[] {});
thisGeneObject = (Gene) constr.newInstance(new Object[] {});
thisGeneObject =
(Gene)
PrivateAccessor.invoke(
thisGeneObject, "newGeneInternal", new Class[] {}, new Object[] {});
}
} catch (Throwable e) {
throw new GeneCreationException(geneClass, e);
}
// Find the text node and fetch the string representation of
// the allele.
// ---------------------------------------------------------
NodeList children = thisGeneElement.getChildNodes();
int childrenSize = children.getLength();
String alleleRepresentation = null;
for (int j = 0; j < childrenSize; j++) {
Element alleleElem = (Element) children.item(j);
if (alleleElem.getTagName().equals(ALLELE_TAG)) {
alleleRepresentation = alleleElem.getAttribute("value");
}
if (children.item(j).getNodeType() == Node.TEXT_NODE) {
// We found the text node. Extract the representation.
// ---------------------------------------------------
alleleRepresentation = children.item(j).getNodeValue();
break;
}
}
// Sanity check: Make sure the representation isn't null.
// ------------------------------------------------------
if (alleleRepresentation == null) {
throw new ImproperXMLException(
"Unable to build Gene instance from XML Element: "
+ "value (allele) is missing representation.");
}
// Now set the value of the gene to that reflect the
// string representation.
// -------------------------------------------------
try {
thisGeneObject.setValueFromPersistentRepresentation(alleleRepresentation);
} catch (UnsupportedOperationException e) {
throw new GeneCreationException(
"Unable to build Gene because it does not support the "
+ "setValueFromPersistentRepresentation() method.");
}
// Finally, add the current gene object to the list of genes.
// ----------------------------------------------------------
genes.add(thisGeneObject);
}
return (Gene[]) genes.toArray(new Gene[genes.size()]);
}
/**
* @param a_gene Gene
* @param a_xmlDocument Document
* @return Element
* @author Klaus Meffert
* @since 2.0
*/
private static Element representAlleleAsElement(final Gene a_gene, final Document a_xmlDocument) {
Element alleleElement = a_xmlDocument.createElement(ALLELE_TAG);
alleleElement.setAttribute("class", a_gene.getClass().getName());
alleleElement.setAttribute("value", a_gene.getPersistentRepresentation());
return alleleElement;
}
