@Test
public void testStrataNamesAndIdsStrataCriterionsTrialSite() {
TrialSite site1 = new TrialSite();
site1.setId(1);
site1.setName("site1");
TrialSite site2 = new TrialSite();
site2.setId(2);
site2.setName("site2");
validTrial.addParticipatingSite(site1);
validTrial.addParticipatingSite(site2);
validTrial.setStratifyTrialSite(true);
DichotomousCriterion criterion1 = new DichotomousCriterion();
criterion1.setId(1);
criterion1.setName("criterion1");
criterion1.setOption1("option1");
criterion1.setOption2("option2");
try {
DichotomousConstraint d1 = new DichotomousConstraint(Arrays.asList(new String[] {"option1"}));
d1.setId(1);
criterion1.addStrata(d1);
DichotomousConstraint d2 = new DichotomousConstraint(Arrays.asList(new String[] {"option2"}));
d2.setId(2);
criterion1.addStrata(d2);
} catch (ContraintViolatedException e) {
fail();
}
DichotomousCriterion criterion2 = new DichotomousCriterion();
criterion2.setId(2);
criterion2.setName("criterion2");
criterion2.setOption1("option1");
criterion2.setOption2("option2");
try {
DichotomousConstraint d1 = new DichotomousConstraint(Arrays.asList(new String[] {"option1"}));
d1.setId(1);
criterion2.addStrata(d1);
DichotomousConstraint d2 = new DichotomousConstraint(Arrays.asList(new String[] {"option2"}));
d2.setId(2);
criterion2.addStrata(d2);
} catch (ContraintViolatedException e) {
fail();
}
validTrial.addCriterion(criterion1);
validTrial.addCriterion(criterion2);
Pair<List<String>, List<String>> pair = validTrial.getAllStrataIdsAndNames();
assertEquals(8, pair.first().size());
assertEquals(8, pair.last().size());
Collections.sort(pair.first());
assertEquals("1__1_1;2_1;", pair.first().get(0));
assertEquals("1__1_1;2_2;", pair.first().get(1));
assertEquals("1__1_2;2_1;", pair.first().get(2));
assertEquals("1__1_2;2_2;", pair.first().get(3));
assertEquals("2__1_1;2_1;", pair.first().get(4));
assertEquals("2__1_1;2_2;", pair.first().get(5));
assertEquals("2__1_2;2_1;", pair.first().get(6));
assertEquals("2__1_2;2_2;", pair.first().get(7));
Collections.sort(pair.last());
assertEquals("site1 | criterion1_option1;criterion2_option1;", pair.last().get(0));
assertEquals("site1 | criterion1_option1;criterion2_option2;", pair.last().get(1));
assertEquals("site1 | criterion1_option2;criterion2_option1;", pair.last().get(2));
assertEquals("site1 | criterion1_option2;criterion2_option2;", pair.last().get(3));
assertEquals("site2 | criterion1_option1;criterion2_option1;", pair.last().get(4));
assertEquals("site2 | criterion1_option1;criterion2_option2;", pair.last().get(5));
assertEquals("site2 | criterion1_option2;criterion2_option1;", pair.last().get(6));
assertEquals("site2 | criterion1_option2;criterion2_option2;", pair.last().get(7));
}
@Test
public void testStrataNamesAndIdsStrataTrialSite() {
TrialSite site1 = new TrialSite();
site1.setId(1);
site1.setName("site1");
TrialSite site2 = new TrialSite();
site2.setId(2);
site2.setName("site2");
TrialSite site3 = new TrialSite();
site3.setId(3);
site3.setName("site3");
TrialSite site4 = new TrialSite();
site4.setId(4);
site4.setName("site4");
validTrial.addParticipatingSite(site1);
validTrial.addParticipatingSite(site2);
validTrial.addParticipatingSite(site3);
validTrial.addParticipatingSite(site4);
validTrial.setStratifyTrialSite(true);
Pair<List<String>, List<String>> pair = validTrial.getAllStrataIdsAndNames();
assertEquals(4, pair.first().size());
assertEquals(4, pair.last().size());
Collections.sort(pair.first());
assertEquals("1__", pair.first().get(0));
assertEquals("2__", pair.first().get(1));
assertEquals("3__", pair.first().get(2));
assertEquals("4__", pair.first().get(3));
Collections.sort(pair.last());
assertEquals("site1", pair.last().get(0));
assertEquals("site2", pair.last().get(1));
assertEquals("site3", pair.last().get(2));
assertEquals("site4", pair.last().get(3));
}
private void randomizeInValidTrialTwoTrialSites31()
throws IllegalArgumentException, TrialStateException {
authenticatAsAdmin();
Person cp1 = new Person();
cp1.setFirstname("Contact");
cp1.setSurname("Person");
cp1.setEmail("*****@*****.**");
cp1.setPhone("1234567");
cp1.setSex(Gender.MALE);
TrialSite trialSite1 = new TrialSite();
trialSite1.setCity("Heidelberg");
trialSite1.setCountry("Germany");
trialSite1.setName("NCT");
trialSite1.setPostcode("69120");
trialSite1.setStreet("INF");
trialSite1.setPassword("1$heidelberg");
trialSite1.setContactPerson(cp1);
trialSiteService.create(trialSite1);
Person cp2 = new Person();
cp2.setFirstname("Contact");
cp2.setSurname("Person");
cp2.setEmail("*****@*****.**");
cp2.setPhone("1234567");
cp2.setSex(Gender.MALE);
TrialSite trialSite2 = new TrialSite();
trialSite2.setCity("Heidelberg");
trialSite2.setCountry("Germany");
trialSite2.setName("NCT2");
trialSite2.setPostcode("69120");
trialSite2.setStreet("INF");
trialSite2.setPassword("1$heidelberg");
trialSite2.setContactPerson(cp2);
trialSiteService.create(trialSite2);
validTrial.addParticipatingSite(trialSite1);
validTrial.addParticipatingSite(trialSite2);
validTrial.setStartDate(new GregorianCalendar(2009, 0, 1));
validTrial.setEndDate(new GregorianCalendar(2009, 11, 1));
authenticatAsPrincipalInvestigator();
int blocksize = 4;
int randomizations = 120;
TreatmentArm arm1 = new TreatmentArm();
arm1.setPlannedSubjects(randomizations / 2);
arm1.setName("arm1");
arm1.setTrial(validTrial);
TreatmentArm arm2 = new TreatmentArm();
arm2.setPlannedSubjects(randomizations / 2);
arm2.setName("arm2");
arm2.setTrial(validTrial);
List<TreatmentArm> arms = new ArrayList<TreatmentArm>();
arms.add(arm1);
arms.add(arm2);
trialService.create(validTrial);
validTrial.setTreatmentArms(arms);
BlockRandomizationConfig config = new BlockRandomizationConfig();
config.setMaximum(blocksize);
config.setMinimum(blocksize);
validTrial.setRandomizationConfiguration(config);
trialService.update(validTrial);
assertTrue(validTrial.getId() > 0);
assertEquals(2, validTrial.getTreatmentArms().size());
Iterator<TrialSite> it = validTrial.getParticipatingSites().iterator();
TrialSite site1 = it.next();
TrialSite site2 = it.next();
authenticatAsInvestigator();
for (int i = 0; i < randomizations; i++) {
TrialSubject subject = new TrialSubject();
subject.setIdentification("identification" + i);
if (i < 90) {
subject.setTrialSite(site1);
} else {
subject.setTrialSite(site2);
}
trialService.randomize(validTrial, subject);
subject.setCreatedAt(new GregorianCalendar(2009, i % 12, 1));
sessionFactory.getCurrentSession().update(subject);
if ((i % blocksize) == (blocksize - 1)) {
assertEquals(
validTrial.getTreatmentArms().get(0).getSubjects().size(),
validTrial.getTreatmentArms().get(1).getSubjects().size());
}
int diff =
validTrial.getTreatmentArms().get(0).getSubjects().size()
- validTrial.getTreatmentArms().get(1).getSubjects().size();
assertTrue((blocksize / 2) >= diff && (-1) * (blocksize / 2) <= diff);
}
Trial dbTrial = trialService.getObject(validTrial.getId());
assertNotNull(dbTrial);
assertEquals(validTrial.getName(), dbTrial.getName());
assertEquals(2, dbTrial.getTreatmentArms().size());
assertEquals(
randomizations,
dbTrial.getTreatmentArms().get(0).getSubjects().size()
+ dbTrial.getTreatmentArms().get(1).getSubjects().size());
assertEquals(randomizations / 2, dbTrial.getTreatmentArms().get(0).getSubjects().size());
assertEquals(randomizations / 2, dbTrial.getTreatmentArms().get(1).getSubjects().size());
}
