/**
   * Is the chromosome missing in this marker?
   *
   * @param marker
   * @return
   */
  boolean isChromosomeMissing(Marker marker) {
    // Missing chromosome in marker?
    if (marker.getChromosome() == null) return true;

    // Missing chromosome in genome?
    String chrName = marker.getChromosomeName();
    Chromosome chr = genome.getChromosome(chrName);
    if (chr == null) return true;

    // Chromosome length is 1 or less?
    if (chr.size() < 1) return true;

    // Tree not found in interval forest?
    if (!intervalForest.hasTree(chrName)) return true;

    // OK, we have the chromosome
    return false;
  }